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Literature summary for 7.2.2.14 extracted from
- The structure of CorA: a Mg(2+)-selective channel (2006), Curr. Opin. Struct. Biol., 16, 432-438.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure analysis, X-ray structure determination at 3.9 A resolution, PDB ID 2BBJ, overview | Thermotoga maritima |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | the CorA monomer has a C-terminal membrane domain containing two transmembrane segments | Thermotoga maritima | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Mg2+/out | Thermotoga maritima | - |
ADP + phosphate + Mg2+/in | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermotoga maritima | - |
gene corA | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Mg2+/out | - |
Thermotoga maritima | ADP + phosphate + Mg2+/in | - |
? | |
| ATP + H2O + Mg2+/out | a fully hydrated Mg2+ binds in the periplasm, interaction of CprA with Mg2+ and transport mechanism, overview | Thermotoga maritima | ADP + phosphate + Mg2+/in | - |
? | |
| additional information | the CorA monomer has a C-terminal membrane domain containing two transmembrane segments, and a large, highly negatively charged N-terminal cytoplasmic soluble domain, the enzyme forms a homopentamer shaped like a funnel with Asn314 at the entrance, which interacts with the ring of positive charges external to the ion conduction pathwayat the cytosolicmembrane interface, in the membrane | Thermotoga maritima | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| pentamer | the CorA monomer has a C-terminal membrane domain containing two transmembrane segments, and a large, highly negatively charged N-terminal cytoplasmic soluble domain, the enzyme forms a homopentamer shaped like a funnel, which interacts with the ring of positive charges external to the ion conduction pathway at the cytosolic membrane interface, in the membrane | Thermotoga maritima |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CorA | - |
Thermotoga maritima |
| More | the enzyme belongs to the CorA Mg2+ transporter superfamily | Thermotoga maritima |
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