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Literature summary for 7.2.2.13 extracted from

  • Booth, A.E.; Tarafder, A.K.; Hume, A.N.; Recchi, C.; Seabra, M.C.
    A role for Na+,K+-ATPase alpha1 in regulating Rab27a localisation on melanosomes (2014), PLoS ONE, 9, e102851.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Cloned(Commentary)

Cloned (Comment) Organism
GST-tagged ATP1a1-M4M5 is expressed in Escherichia coli BL21-codon plus (DE3) RILP cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + 3 Na+/in + 2 K+/out Mus musculus
-
 ADP + phosphate + 3 Na+/out + 2 K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography, and gel filtration Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
melanocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 3 Na+/in + 2 K+/out
-
 Mus musculus ADP + phosphate + 3 Na+/out + 2 K+/in
-
 ?

Synonyms

Synonyms Comment Organism
ATP1a1 subunit of Na+,K+-ATPase isoform 1 Mus musculus
Na+,K+-ATPase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction depletion of subunit ATP1a1 reduces the level of active Rab27a in melanocytes and ist targeting to melanosomes Mus musculus
physiological function subunit ATP1a1 plays an essential role in Rab27a-dependent melanosome transport. The subunit is essential for targeting and activation of Rab27a to melanosomes Mus musculus