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Literature summary for 7.2.2.13 extracted from

  • Doganli, C.; Kjaer-Sorensen, K.; Knoeckel, C.; Beck, H.C.; Nyengaard, J.R.; Honore, B.; Nissen, P.; Ribera, A.; Oxvig, C.; Lykke-Hartmann, K.
    The alpha2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish (2012), J. Cell Sci., 125, 6166-6175.
    View publication on PubMed
Search for more literature for 7.2.2.13

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Danio rerio
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-
striated muscle
-
 Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Danio rerio ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
alpha2Na+/K+-ATPase subunit Danio rerio
Na+,K+-ATPase
-
 Danio rerio

General Information

General Information Comment Organism
malfunction knockdown causes a significant depolarization of the resting membrane potential in slow-twitch fibers of skeletal muscles. Abrupt mechanosensory responses are observed in alpha2Na+/K+-ATPase-deficient embryos, possibly linked to a postsynaptic defect. The enzyme deficiency reduces the heart rate and causes a loss of left-right asymmetry in the heart tube Danio rerio
physiological function alpha2Na+/K+-ATPase is important for skeletal and heart muscle function Danio rerio