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Literature summary for 7.2.2.13 extracted from

  • Sopjani, M.; Alesutan, I.; Dermaku-Sopjani, M.; Gu, S.; Zelenak, C.; Munoz, C.; Velic, A.; Foeller, M.; Rosenblatt, K.P.; Kuro-o, M.; Lang, F.
    Regulation of the Na+/K+ ATPase by Klotho (2011), FEBS Lett., 585, 1759-1764.
    View publication on PubMed
Search for more literature for 7.2.2.13

Organism

Organism UniProt Comment Textmining
Mus musculus
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Xenopus laevis
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Source Tissue

Source Tissue Comment Organism Textmining
oocyte
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 Xenopus laevis
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General Information

General Information Comment Organism
physiological function Klotho is a transmembrane protein with particularly strong expression in kidney, parathyroid glands and choroid plexus. Expression of Klotho in Xenopus oocytes increases the Na+/K+ ATPase pump current. Treatment of Xenopus oocytes with Klotho protein similarly increases the pump current Xenopus laevis
physiological function Klotho is a transmembrane protein with particularly strong expression in kidney, parathyroid glands and choroid plexus. Klotho-hypomorphic mice suffer from renal salt wasting and hypovolemia despite hyperaldosteronism. Na+/K+ ATPase protein abundance in isolated collecting ducts is lower in Klothohm mice than in their wild type littermates Mus musculus