Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.13 extracted from

  • Garcia, D.G.; Amorim, L.M.; de Castro Faria, M.V.; Freire, A.S.; Santelli, R.E.; Da Fonseca, C.O.; Quirico-Santos, T.; Burth, P.
    The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor (2010), Mol. Cell. Biochem., 345, 29-34.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
Ouabain
-
 Cavia porcellus
Ouabain
-
 Homo sapiens
perillyl alcohol a monoterpene, inhibits Na/K-ATPase, non-competitive inhibition for Na+ and K+ and an uncompetitive inhibition for ATP in brain and kidney Cavia porcellus
perillyl alcohol a monoterpene, inhibits Na/K-ATPase showing a noncompetitive inhibition profile to Na+ and K+ and an uncompetitive inhibition towards ATP. The generated electrochemical gradient is essential for a number of other cellular functions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Cavia porcellus 5886
-
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Na+/in + K+/out Cavia porcellus
-
 ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out Homo sapiens
-
 ADP + phosphate + Na+/out + K+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme partially from brain and kidney Cavia porcellus

Source Tissue

Source Tissue Comment Organism Textmining
A-172 cell glioblastoma cells, A172 cells overexpress Na/K-ATPase alpha1 isoform in the caveolar structure Homo sapiens
-
brain
-
 Cavia porcellus
-
kidney
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Cavia porcellus ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 Homo sapiens ADP + phosphate + Na+/out + K+/in
-
 ?

Synonyms

Synonyms Comment Organism
Na/K-ATPase
-
 Cavia porcellus
Na/K-ATPase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cavia porcellus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Cavia porcellus
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, overview Cavia porcellus
additional information
-
 additional information inhibition kinetics, overview Homo sapiens
1.5
-
 perillyl alcohol pH 7.4, 37°C, Na/K-ATPase-enriched A-127 cell extract Homo sapiens

General Information

General Information Comment Organism
physiological function Na/K-ATPase is a plasma membrane protein complex transferring the stored energy of ATP to the active transport of Na+ and K+ ions across the cell membrane. Na/K-ATPase alpha1 isoform modulates signaling mechanisms leading to apoptosis, cell migration, and cell proliferation Homo sapiens
physiological function Na/K-ATPase is a plasma membrane protein complex transferring the stored energy of ATP to the active transport of Na+ and K+ ions across the cell membrane. The generated electrochemical gradient is essential for a number of other cellular functions Cavia porcellus