Application | Comment | Organism |
---|---|---|
medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Mus musculus |
medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Rattus norvegicus |
medicine | the positive inotropic effect produced by Na+/K+-ATPase inhibition is used for the treatment of heart failure | Felis catus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the cat at 25 nM a 43% decrease in cell viability due to apoptosis and necrosis | Felis catus | |
Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis.The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy | Mus musculus | |
Ouabain | ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. The NCX inhibitor KB-R7943 and by the CaMKII inhibitors, KN93 and AIP prevent ouabain-induced apoptosis without affecting inotropy. Ouabain produces in the rat at 0.002 mM a 43% decrease in cell viability due to apoptosis and necrosis | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
membrane | - |
Felis catus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in + K+/out | Mus musculus | - |
ADP + phosphate + Na+/out + K+/in | - |
? | |
ATP + H2O + Na+/in + K+/out | Rattus norvegicus | - |
ADP + phosphate + Na+/out + K+/in | - |
? | |
ATP + H2O + Na+/in + K+/out | Felis catus | - |
ADP + phosphate + Na+/out + K+/in | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Felis catus | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiac myocyte | - |
Mus musculus | - |
cardiac myocyte | - |
Rattus norvegicus | - |
cardiac myocyte | - |
Felis catus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + Na+/in + K+/out | - |
Mus musculus | ADP + phosphate + Na+/out + K+/in | - |
? | |
ATP + H2O + Na+/in + K+/out | - |
Rattus norvegicus | ADP + phosphate + Na+/out + K+/in | - |
? | |
ATP + H2O + Na+/in + K+/out | - |
Felis catus | ADP + phosphate + Na+/out + K+/in | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Na+/K+-ATPase | - |
Mus musculus |
Na+/K+-ATPase | - |
Rattus norvegicus |
Na+/K+-ATPase | - |
Felis catus |
General Information | Comment | Organism |
---|---|---|
additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Mus musculus |
additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Rattus norvegicus |
additional information | Na+,K+-ATPase inhibitor ouabain triggers an apoptotic cascade that involves NCX and CaMKII as a downstream effector. Ouabain simultaneously activates an antiapoptotic cascade involving PI3K/AKT which is however, insufficient to completely repress apoptosis. KN93 prevents ouabain-induced apoptosis without affecting inotropy | Felis catus |