Literature summary for 7.2.2.13 extracted from

Gramigni, E.; Tadini-Buoninsegni, F.; Bartolommei, G.; Santini, G.; Chelazzi, G.; Moncelli, M.R.
Inhibitory effect of Pb2+ on the transport cycle of the Na+,K+-ATPase (2009), Chem. Res. Toxicol., 22, 1699-1704.

Search for more literature for 7.2.2.13

Inhibitors

Inhibitors	Comment	Organism	Structure
Ouabain	complete inhibition at 0.001 mM	Oryctolagus cuniculus
Pb2+	inhibitory effect of Pb2+ on the transport cycle of the Na+,K+-ATPase, overview. Pb2+ inhibits cycling of the enzyme, but it does not affect cytoplasmic Na+ binding and release of Na+ ions at the extracellular side at concentrations below 0.010 mM	Oryctolagus cuniculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Oryctolagus cuniculus	5886	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Na+/in + K+/out	Oryctolagus cuniculus	-	ADP + phosphate + Na+/out + K+/in	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	New Zealand white rabbit	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	outer medulla	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Na+/in + K+/out	-	Oryctolagus cuniculus	ADP + phosphate + Na+/out + K+/in	-	?
additional information	assay using solid-supported membrane, overview	Oryctolagus cuniculus	?	-	?

Synonyms

Synonyms	Comment	Organism
Na+,K+-ATPase	-	Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Oryctolagus cuniculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)