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Literature summary for 7.2.2.13 extracted from

  • Ribeiro, C.A.; Leipnitz, G.; Amaral, A.U.; de Bortoli, G.; Seminotti, B.; Wajner, M.
    Creatine administration prevents Na+,K+-ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats (2009), Brain Res., 1262, 81-88.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
isovaleric acid isovaleric acid injection significantly inhibits Na+,K+-ATPase activity by 25% in cerebral cortex of rats 2 or 24 h after administration, while pre-treatment of rats with creatine completely prevents the inhibitory effects of isovaleric acid on Na+,K+-ATPase Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
Na+,K+-ATPase
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism in vivo administration of isovaleric acid inhibits the citric acid cycle probably through the enzyme citrate synthase, as well as Na+,K+-ATPase, a crucial enzyme responsible for maintaining the basal potential membrane necessary for a normal neurotransmission, inhibition of these activities may be involved in the pathophysiology of the neurological dysfunction of isovaleric academic patients. Isovaleric acidemia is an autosomal recessive inherited metabolic disorder of leucine metabolism caused by a deficiency of isovaleryl-CoA dehydrogenase Rattus norvegicus