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Literature summary for 7.2.2.13 extracted from

  • Vinciguerra, M.; Mordasini, D.; Vandewalle, A.; Feraille, E.
    Hormonal and nonhormonal mechanisms of regulation of the NA,K-pump in collecting duct principal cells (2005), Semin. Nephrol., 25, 312-321.
    View publication on PubMed
Search for more literature for 7.2.2.13

Activating Compound

Activating Compound Comment Organism Structure
aldosterone control of Na,K-ATPase activity and expression Mammalia
Insulin control of Na,K-ATPase activity and expression Mammalia
sodium control of Na,K-ATPase activity and expression by intracellular Na+ Mammalia
Vasopressin control of Na,K-ATPase activity and expression Mammalia

Inhibitors

Inhibitors Comment Organism Structure
alpha2-adrenergic agonists negative modulator Mammalia
bradykinin negative modulator Mammalia
dopamine negative modulator Mammalia
endothelin negative modulator Mammalia
Prostaglandins negative modulator Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mammalia 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + Na+/out Mammalia each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in Mammalia
-
 ADP + phosphate + K+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
collecting duct
-
 Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + Na+/out
-
 Mammalia ATP + H2O + Na+/in
-
 ?
ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Mammalia ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in
-
 Mammalia ADP + phosphate + K+/out
-
 ?

Subunits

Subunits Comment Organism
heterodimer alphabeta Mammalia

Synonyms

Synonyms Comment Organism
Na,K-adenosine triphosphatase
-
 Mammalia
Na,K-ATPase
-
 Mammalia
Na,K-Pump
-
 Mammalia
sodium pump
-
 Mammalia