Any feedback?
Literature summary for 7.2.2.13 extracted from
- Structure-function relationships in the Na+,K+-pump (2005), Semin. Nephrol., 25, 282-291.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| refinement to 9-11 A | Mammalia |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ouabain | interaction is dependent on the conformation and phosphorylation state of the protein | Mammalia |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 7000 | - |
gamma subunit: 6500-7500 Da, identified in kidney tissue | Mammalia |
| 35000 | - |
beta subunit | Mammalia |
| 112000 | - |
alpha subunit | Mammalia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + Na+/out | Mammalia | each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP | ATP + H2O + Na+/in | - |
r | |
| ATP + H2O + K+/in | Mammalia | - |
ADP + phosphate + K+/out | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | beta subunit | Mammalia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + Na+/out | - |
Mammalia | ATP + H2O + Na+/in | - |
r | |
| ADP + phosphate + Na+/out | each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP | Mammalia | ATP + H2O + Na+/in | - |
r | |
| ATP + H2O + K+/in | - |
Mammalia | ADP + phosphate + K+/out | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | alphabeta, minimal functional unit, aggrgation of protomeric units is a common observation | Mammalia |
| trimer | alphabetagamma | Mammalia |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na(+)-K(+)-exchanging ATPase | - |
Mammalia |
| Na+,K+-adenosine triphosphatase | - |
Mammalia |
| Na+,K+-ATPase | - |
Mammalia |
| Na+,K+-pump | - |
Mammalia |
| Na,K-Pump | - |
Mammalia |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
