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Literature summary for 7.2.2.13 extracted from

  • William, M.; Vien, J.; Hamilton, E.; Garcia, A.; Bundgaard, H.; Clarke Ronald, J.; Rasmussen Helge, H.
    The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes (2005), J. Physiol., 565, 815-825.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.13

Activating Compound

Activating Compound Comment Organism Structure
8-pCPT-CGMP induces a concentration-dependent increase in pump current, activator of PKG Oryctolagus cuniculus
sodium nitroprusside SNP, NO donor, not a simple concentration-dependent effect on pump current Oryctolagus cuniculus
YC-1 activator of soluble guanylyl cyclase, sGC Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one ODQ, inhibition of SNP-induced pump stimulation Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
sarcolemma
-
 Oryctolagus cuniculus 42383
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + Na+/out Oryctolagus cuniculus
-
 ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in Oryctolagus cuniculus
-
 ADP + phosphate + K+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myocyte ventricular myocyte Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + Na+/out
-
 Oryctolagus cuniculus ATP + H2O + Na+/in
-
 ?
ATP + H2O + K+/in
-
 Oryctolagus cuniculus ADP + phosphate + K+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-K+ ATPase
-
 Oryctolagus cuniculus
Na+-K+ pump
-
 Oryctolagus cuniculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2 8 K+ predicted, in the presence of 5.6 mM external K+ Oryctolagus cuniculus
3 6 K+ predicted, in the presence of 15 mM external K+ Oryctolagus cuniculus