Any feedback?
Literature summary for 7.2.2.13 extracted from
- Tumor necrosis factor alpha down-regulates the Na+-K+ ATPase and the Na+-K+2Cl- cotransporter in the kidney cortex and medulla (2006), Cytokine, 33, 138-144.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ouabain | - |
Rattus norvegicus |  |
| prostaglandin E2 | PGE2 | Rattus norvegicus | |
| Tumor necrosis factor alpha | TNF-alpha, TNF-alpha affects the Na+-K+ pump via PGE2-dependent pathways | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
beta subunit, glycoprotein, 35-55kDa | Rattus norvegicus |
| 110000 | - |
alpha subunit, 110-113kDa | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + Na+/out | Rattus norvegicus | - |
ATP + H2O + Na+/in | - |
? | |
| ATP + H2O + K+/in | Rattus norvegicus | - |
ADP + phosphate + K+/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney cortex | - |
Rattus norvegicus | - |
| kidney medulla | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + phosphate + Na+/out | - |
Rattus norvegicus | ATP + H2O + Na+/in | - |
? | |
| ATP + H2O + K+/in | - |
Rattus norvegicus | ADP + phosphate + K+/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | heterodimer, catalytic alpha subunit, beta subunit | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na+-K+ ATPase | - |
Rattus norvegicus |
| Na+-K+ pump | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
activity assay | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
activity assay | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
