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Literature summary for 7.2.2.13 extracted from

  • Robinson, J.D.; Flashner, M.S.
    The (Na+ + K+)-activated ATPase. Enzymic and transport properties (1979), Biochim. Biophys. Acta, 549, 145-176.
    View publication on PubMed
Search for more literature for 7.2.2.13

Inhibitors

Inhibitors Comment Organism Structure
oligomycin inhibits (Na+,K+)-ATPase reaction and Na+-ATPase reaction, has little effect on the K+-phosphatase reaction and can stimulate the ADP/ATP exchange reaction Mammalia
oubain
-
 Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mammalia

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
250000 300000 radiation inactivation , gel filtration Mammalia
380000
-
 equilibrium centrifugation Mammalia

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-
Mammalia
-
-
-
shark
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1] reaction sequence and transport mechanism Mammalia
a

Source Tissue

Source Tissue Comment Organism Textmining
electric organ
-
 Electrophorus electricus
-
kidney medulla Mammalia
-
rectal gland
-
 shark
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Na+/in + K+/out
-
 Mammalia ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 shark ADP + phosphate + Na+/out + K+/in
-
 ?
ATP + H2O + Na+/in + K+/out
-
 Electrophorus electricus ADP + phosphate + Na+/out + K+/in
-
 ?
additional information the enzyme also catalyzes: 1. uncoupled Na+ efflux in presence of Na+/in, Mg2+ and ATP, 2. Na+-dependent ADP/ATP exchange, 3. K+-dependent enzyme phosphorylation by phosphate Mammalia ?
-
 ?