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Literature summary for 7.2.2.12 extracted from

  • Maunders, E.A.; Ganio, K.; Hayes, A.J.; Neville, S.L.; Davies, M.R.; Strugnell, R.A.; McDevitt, C.A.; Tan, A.
    The role of ZntA in Klebsiella pneumoniae zinc homeostasis (2022), Microbiol. Spectr., 10, e0177321.
    View publication on PubMed
Search for more literature for 7.2.2.12

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+[side 1] Klebsiella pneumoniae
-
 ADP + phosphate + Zn2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1] Klebsiella pneumoniae AJ218
-
 ADP + phosphate + Zn2+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae AJ218
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Zn2+[side 1]
-
 Klebsiella pneumoniae ADP + phosphate + Zn2+[side 2]
-
 ?
ATP + H2O + Zn2+[side 1]
-
 Klebsiella pneumoniae AJ218 ADP + phosphate + Zn2+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
P-type ATPase ZntA
-
 Klebsiella pneumoniae

Expression

Organism Comment Expression
Klebsiella pneumoniae upregulated in response to cellular zinc stress up

General Information

General Information Comment Organism
malfunction deletion of zntA renders Klebsiella pneumoniae AJ218 highly susceptible to exogenous zinc stress and manifests as an impaired growth phenotype and increased cellular accumulation of the metal. Loss of zntA also increases sensitivity to cadmium stress, indicating a role for this efflux pathway in cadmium resistance. Disruption of zinc homeostasis in the Klebsiella pneumoniae AJ218 DzntA strain also impacts manganese and iron homeostasis and is associated with increased production of biofilm Klebsiella pneumoniae
physiological function critical role of ZntA in zinc tolerance Klebsiella pneumoniae