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Literature summary for 7.2.2.12 extracted from

  • Mandal, P.K.; Mandal, A.; Ahearn, G.A.
    65Zn2+ transport by lobster hepatopancreatic lysosomal membrane vesicles (2006), J. Exp. Zool., 305A, 203-214.
No PubMed abstract available
Search for more literature for 7.2.2.12

Activating Compound

Activating Compound Comment Organism Structure
additional information stimulated by an outwardly directed proton gradient Homarus americanus

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ competitive inhibitor Homarus americanus
Cu2+ competitive inhibitor Homarus americanus
thapsigargin
-
 Homarus americanus
vanadate
-
 Homarus americanus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0148
-
 Zn2+ pH condition outward gradient, pH = 5.0/7.0 Homarus americanus
0.0323
-
 Zn2+
-
 Homarus americanus
0.03589
-
 Zn2+ carrier transport is stimulated by the addition of 1 mM ATP Homarus americanus
0.0413
-
 Zn2+ pH condition equal, pH = 7.0/7.0 Homarus americanus
0.072
-
 Zn2+ pH condition equal, pH = 5.0/5.0 Homarus americanus
0.2288
-
 Zn2+ pH condition inward gradient, pH = 7.0/5.0 Homarus americanus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosomal membrane lysosomal membrane vesicle, LMV Homarus americanus 5765
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Zn2+/out Homarus americanus
-
 ADP + phosphate + Zn2+/in
-
 ?

Organism

Organism UniProt Comment Textmining
Homarus americanus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
lysosomal membrane vesicles are prepared Homarus americanus

Source Tissue

Source Tissue Comment Organism Textmining
hepatopancreas
-
 Homarus americanus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.001242
-
-
 Homarus americanus
0.001584
-
 pH condition equal, pH = 7.0/7.0 Homarus americanus
0.001668
-
 pH condition equal, pH = 5.0/5.0 Homarus americanus
0.001866
-
 pH condition outward gradient, pH = 5.0/7.0 Homarus americanus
0.001916
-
 carrier transport is stimulated by the addition of 1 mM ATP Homarus americanus
0.002082
-
 pH condition inward gradient, pH = 7.0/5.0 Homarus americanus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/out
-
 Homarus americanus ADP + phosphate + Ca2+/in
-
 ?
ATP + H2O + Cd2+/out
-
 Homarus americanus ADP + phosphate + Cd2+/in
-
 ?
ATP + H2O + Cu2+/out
-
 Homarus americanus ADP + phosphate + Cu2+/in
-
 ?
ATP + H2O + Zn2+/out
-
 Homarus americanus ADP + phosphate + Zn2+/in
-
 ?

Synonyms

Synonyms Comment Organism
P-type ATPase
-
 Homarus americanus
SERCA-like ATPase SERCA, ER Sarco-Endoplasmic Reticulum Calcium ATPase Homarus americanus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
 Zn2+ transport measurement at room temperature Homarus americanus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 Zn2+ transport measurement at room temperature Homarus americanus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0327
-
 Cu2+
-
 Homarus americanus
0.0681
-
 Cd2+
-
 Homarus americanus