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Literature summary for 7.2.2.12 extracted from

  • Mills, R.F.; Francini, A.; Ferreira da Rocha, P.S.; Baccarini, P.J.; Aylett, M.; Krijger, G.C.; Williams, L.E.
    The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels (2005), FEBS Lett., 579, 783-791.
    View publication on PubMed
Search for more literature for 7.2.2.12

Protein Variants

Protein Variants Comment Organism
C357G mutant enzyme does not confer Cd and Zn resistance to yeast Arabidopsis thaliana
additional information AtHMA4 and a truncated form lacking the last 457 amino acids both confer Cd and Zn resistance to yeast Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Cd2+/in Arabidopsis thaliana AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance ADP + phosphate + Cd2+/out
-
 ?
ATP + H2O + Zn2+/in Arabidopsis thaliana AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance ADP + phosphate + Zn2+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
 ecotype Columbia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+/in AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance Arabidopsis thaliana ADP + phosphate + Cd2+/out
-
 ?
ATP + H2O + Zn2+/in AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance Arabidopsis thaliana ADP + phosphate + Zn2+/out
-
 ?

Synonyms

Synonyms Comment Organism
AtHMA4
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 Arabidopsis thaliana