Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.10 extracted from

  • Bates, S.; MacCallum, D.M.; Bertram, G.; Munro, C.A.; Hughes, H.B.; Buurman, E.T.; Brown, A.J.; Odds, F.C.; Gow, N.A.
    Candida albicans Pmr1p, a secretory pathway P-type Ca2+/Mn2+-ATPase, is required for glycosylation and virulence (2005), J. Biol. Chem., 280, 23408-23415.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene PM1 homologue, DNA and amino acid sequence determination and analysis Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information disruption of gene PMR1 homologue CaPMR1 leads to inhibition of many Golgi-located, Mn2+-dependent mannosyltransferases, the Capmr1DELTA null mutant is viable in vitro and without phenotype on media supplemented with Ca2+ and Mn2+, but loose viability on minimal medium with low Ca2+/Mn2+ concentrations and enter in stationary phase, growth and glycosylation defects, overview Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Candida albicans 5794
-
membrane
-
Candida albicans 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+/cis Candida albicans Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities ADP + phosphate + Ca2+/trans
-
?
ATP + H2O + Mn2+/cis Candida albicans Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities ADP + phosphate + Mn2+/trans
-
?
additional information Candida albicans the enzyme is a P-type Ca2+/Mn2+-ATPase involved in the secretory pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans Q9P872 several strains, gene PMR1 homologue
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities Candida albicans ADP + phosphate + Ca2+/trans
-
?
ATP + H2O + Mn2+/cis Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities Candida albicans ADP + phosphate + Mn2+/trans
-
?
additional information the enzyme is a P-type Ca2+/Mn2+-ATPase involved in the secretory pathway Candida albicans ?
-
?

Synonyms

Synonyms Comment Organism
P-type Ca2+/Mn2+-ATPase
-
Candida albicans
Pmr1p
-
Candida albicans