Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.10 extracted from

  • Vanoevelen, J.; Dode, L.; Van Baelen, K.; Fairclough, R.J.; Missiaen, L.; Raeymaekers, L.; Wuytack, F.
    The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions (2005), J. Biol. Chem., 280, 22800-22808.
    View publication on PubMed
Search for more literature for 7.2.2.10

Cloned(Commentary)

Cloned (Comment) Organism
gene ATP2C2, expression pattern, chromosomal localization 16q24.1, the genes ATP2C1 and ATP2C2 present an identical exon/intron layout, overview, functional expression of SPCA2 in COS-1 cell microsomes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the Ca2+ and Mn2+ transport of SPCA2 is insensitive to thapsigargin inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the enzyme shows high affinity for Ca2+ Homo sapiens
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + Ca2+/cis Homo sapiens Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities ADP + phosphate + Ca2+/trans
-
 ?
ATP + H2O + Mn2+/cis Homo sapiens Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities ADP + phosphate + Mn2+/trans
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75185 gene ATP2C2; gene ATP2C2
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + Ca2+[side 1] = ADP + phosphate + Ca2+[side 2] isozyme SPCA2 shows Ca2+- and Mn2+-dependent phosphoprotein intermediate formation Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
gastrointestinal tract
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
mammary gland
-
 Homo sapiens
-
additional information SPCA2 expression pattern, overview Homo sapiens
-
prostate gland
-
 Homo sapiens
-
respiratory tract
-
 Homo sapiens
-
salivary gland
-
 Homo sapiens
-
thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/cis Ca2+-dependent ATPase and ATP-dependent Ca2+ transport activities Homo sapiens ADP + phosphate + Ca2+/trans
-
 ?
ATP + H2O + Mn2+/cis Mn2+-dependent ATPase and ATP-dependent Mn2+ transport activities Homo sapiens ADP + phosphate + Mn2+/trans
-
 ?

Synonyms

Synonyms Comment Organism
Ca2+/Mn2+-ATPase 2
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens