Literature summary for 7.2.1.1 extracted from

Bogachev, A.V.; Belevich, N.P.; Bertsova, Y.V.; Verkhovsky, M.I.
Primary steps of the Na+-translocating NADH:ubiquinone oxidoreductase catalytic cycle resolved by the ultrafast freeze-quench approach (2009), J. Biol. Chem., 284, 5533-5538.

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Inhibitors

Inhibitors	Comment	Organism	Structure
NAD+	competitive inhibitor	Vibrio harveyi

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Vibrio harveyi	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADH + H+ + ubiquinone + n Na+/in	Vibrio harveyi	Na+-NQR reduction is not limited by the rate of NADH binding	NAD+ + ubiquinol + n Na+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Vibrio harveyi	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Vibrio harveyi

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + H+ + ubiquinone + n Na+/in	Na+-NQR reduction is not limited by the rate of NADH binding	Vibrio harveyi	NAD+ + ubiquinol + n Na+/out	-	?

Synonyms

Synonyms	Comment	Organism
Na+-translocating NADH:ubiquinone oxidoreductase	-	Vibrio harveyi
sodium-translocating NADH:quinone oxidoreductase	-	Vibrio harveyi

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Vibrio harveyi
FMN	two covalently bound FMNs	Vibrio harveyi
NADH	-	Vibrio harveyi
riboflavin	-	Vibrio harveyi
ubiquinone-8	-	Vibrio harveyi
[2Fe-2S]-center	-	Vibrio harveyi

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
11	-	NAD+	at 30°C, 100 mM KCl, 20 mM HEPES/Tris (pH 7.5)	Vibrio harveyi

General Information

General Information	Comment	Organism
physiological function	Na+-NQR is a component of respiratory chain and generates a redox-driven transmembrane electrochemical Na+ potential	Vibrio harveyi

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Release 2023.1 (January 2023)