Any feedback?
Literature summary for 7.2.1.1 extracted from
- Sodium-translocating NADH:quinone oxidoreductase as a redox-driven ion pump (2010), Biochim. Biophys. Acta, 1797, 738-746.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Haemophilus influenzae |  |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Klebsiella pneumoniae | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Neisseria gonorrhoeae | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Neisseria meningitidis | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Porphyromonas gingivalis | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Pseudomonas aeruginosa | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Vibrio alginolyticus | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Vibrio cholerae serotype O1 | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Vibrio harveyi | |
| 2-n-heptyl-4-hydroxyquinoline-N-oxide | - |
Yersinia pestis | |
| Ag+ | - |
Azotobacter vinelandii | |
| Ag+ | - |
Haemophilus influenzae | |
| Ag+ | - |
Neisseria gonorrhoeae | |
| Ag+ | - |
Neisseria meningitidis | |
| Ag+ | - |
Porphyromonas gingivalis | |
| Ag+ | - |
Pseudomonas aeruginosa | |
| Ag+ | - |
Vibrio alginolyticus | |
| Ag+ | - |
Vibrio cholerae serotype O1 | |
| Ag+ | - |
Vibrio harveyi | |
| Ag+ | - |
Yersinia pestis | |
| Cd2+ | - |
Azotobacter vinelandii | |
| Cd2+ | - |
Haemophilus influenzae | |
| Cd2+ | - |
Klebsiella pneumoniae | |
| Cd2+ | - |
Neisseria gonorrhoeae | |
| Cd2+ | - |
Neisseria meningitidis | |
| Cd2+ | - |
Porphyromonas gingivalis | |
| Cd2+ | - |
Pseudomonas aeruginosa | |
| Cd2+ | - |
Vibrio alginolyticus | |
| Cd2+ | - |
Vibrio cholerae serotype O1 | |
| Cd2+ | - |
Vibrio harveyi | |
| Cd2+ | - |
Yersinia pestis | |
| Cu2+ | - |
Azotobacter vinelandii | |
| Cu2+ | - |
Haemophilus influenzae | |
| Cu2+ | - |
Klebsiella pneumoniae | |
| Cu2+ | - |
Neisseria gonorrhoeae | |
| Cu2+ | - |
Neisseria meningitidis | |
| Cu2+ | - |
Porphyromonas gingivalis | |
| Cu2+ | - |
Pseudomonas aeruginosa | |
| Cu2+ | - |
Vibrio alginolyticus | |
| Cu2+ | - |
Vibrio cholerae serotype O1 | |
| Cu2+ | - |
Vibrio harveyi | |
| Cu2+ | - |
Yersinia pestis | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Azotobacter vinelandii | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Klebsiella pneumoniae | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Neisseria gonorrhoeae | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Neisseria meningitidis | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Porphyromonas gingivalis | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Pseudomonas aeruginosa | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Vibrio alginolyticus | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Vibrio cholerae serotype O1 | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Vibrio harveyi | |
| korormicin | specifically inhibits Na+-NQR at the level of its interaction with ubiquinone | Yersinia pestis | |
| additional information | Na+-NQR from Azotobacter vinelandii is not sensitive to low 2-n-heptyl-4-hydroxyquinoline-N-oxide concentrations | Azotobacter vinelandii | |
| additional information | korormicin has no effect on the enzyme from Haemophilus influenza | Haemophilus influenzae | |
| additional information | Na+-NQR from Klebsiella pneumoniae is fully resistant to either Ag+ or N-ethylmaleimide | Klebsiella pneumoniae | |
| N-ethylmaleimide | - |
Azotobacter vinelandii | |
| N-ethylmaleimide | - |
Haemophilus influenzae | |
| N-ethylmaleimide | - |
Neisseria gonorrhoeae | |
| N-ethylmaleimide | - |
Neisseria meningitidis | |
| N-ethylmaleimide | - |
Porphyromonas gingivalis | |
| N-ethylmaleimide | - |
Pseudomonas aeruginosa | |
| N-ethylmaleimide | - |
Vibrio alginolyticus | |
| N-ethylmaleimide | - |
Vibrio cholerae serotype O1 | |
| N-ethylmaleimide | - |
Vibrio harveyi | |
| N-ethylmaleimide | - |
Yersinia pestis | |
| Pb2+ | - |
Azotobacter vinelandii | |
| Pb2+ | - |
Haemophilus influenzae | |
| Pb2+ | - |
Klebsiella pneumoniae | |
| Pb2+ | - |
Neisseria gonorrhoeae | |
| Pb2+ | - |
Neisseria meningitidis | |
| Pb2+ | - |
Porphyromonas gingivalis | |
| Pb2+ | - |
Pseudomonas aeruginosa | |
| Pb2+ | - |
Vibrio alginolyticus | |
| Pb2+ | - |
Vibrio cholerae serotype O1 | |
| Pb2+ | - |
Vibrio harveyi | |
| Pb2+ | - |
Yersinia pestis | |
| Zn2+ | - |
Azotobacter vinelandii | |
| Zn2+ | - |
Haemophilus influenzae | |
| Zn2+ | - |
Klebsiella pneumoniae | |
| Zn2+ | - |
Neisseria gonorrhoeae | |
| Zn2+ | - |
Neisseria meningitidis | |
| Zn2+ | - |
Porphyromonas gingivalis | |
| Zn2+ | - |
Pseudomonas aeruginosa | |
| Zn2+ | - |
Vibrio alginolyticus | |
| Zn2+ | - |
Vibrio cholerae serotype O1 | |
| Zn2+ | - |
Vibrio harveyi | |
| Zn2+ | - |
Yersinia pestis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Haemophilus influenzae | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Vibrio harveyi | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Pseudomonas aeruginosa | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Neisseria gonorrhoeae | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Neisseria meningitidis | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Klebsiella pneumoniae | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Azotobacter vinelandii | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Yersinia pestis | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Porphyromonas gingivalis | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Vibrio cholerae serotype O1 | |
| Na+ | specific requirement for sodium ions, even in the absence of sodium ions Na+-NQR is unable to translocate protons | Vibrio alginolyticus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21500 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
| 22700 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
| 27500 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
| 45200 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
| 45400 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
| 48400 | - |
1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Haemophilus influenzae | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio harveyi | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Pseudomonas aeruginosa | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Neisseria gonorrhoeae | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Neisseria meningitidis | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Klebsiella pneumoniae | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Azotobacter vinelandii | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Yersinia pestis | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Porphyromonas gingivalis | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio cholerae serotype O1 | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio alginolyticus | - |
deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| additional information | Haemophilus influenzae | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Vibrio harveyi | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Pseudomonas aeruginosa | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Neisseria gonorrhoeae | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Neisseria meningitidis | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Klebsiella pneumoniae | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Azotobacter vinelandii | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Yersinia pestis | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Porphyromonas gingivalis | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Vibrio cholerae serotype O1 | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Vibrio alginolyticus | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | ? | - |
? | |
| additional information | Haemophilus influenzae | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Vibrio harveyi | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Pseudomonas aeruginosa | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Neisseria gonorrhoeae | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Neisseria meningitidis | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Klebsiella pneumoniae | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Azotobacter vinelandii | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Yersinia pestis | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Porphyromonas gingivalis | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Vibrio cholerae serotype O1 | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| additional information | Vibrio alginolyticus | Na+-NQR does not oxidize NADPH | ? | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Haemophilus influenzae | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Vibrio harveyi | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Pseudomonas aeruginosa | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Neisseria gonorrhoeae | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Neisseria meningitidis | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Klebsiella pneumoniae | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Azotobacter vinelandii | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Yersinia pestis | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Porphyromonas gingivalis | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Vibrio cholerae serotype O1 | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | Vibrio alginolyticus | - |
NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Haemophilus influenzae | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio harveyi | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Pseudomonas aeruginosa | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Neisseria gonorrhoeae | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Neisseria meningitidis | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Klebsiella pneumoniae | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Azotobacter vinelandii | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Yersinia pestis | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Porphyromonas gingivalis | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio cholerae serotype O1 | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | Vibrio alginolyticus | - |
thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Azotobacter vinelandii | - |
- |
- |
| Haemophilus influenzae | - |
- |
- |
| Klebsiella pneumoniae | - |
- |
- |
| Neisseria gonorrhoeae | - |
- |
- |
| Neisseria meningitidis | - |
- |
- |
| Porphyromonas gingivalis | - |
- |
- |
| Pseudomonas aeruginosa | - |
- |
- |
| Vibrio alginolyticus | - |
- |
- |
| Vibrio cholerae serotype O1 | - |
- |
- |
| Vibrio harveyi | - |
- |
- |
| Yersinia pestis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Haemophilus influenzae | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio harveyi | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Pseudomonas aeruginosa | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria gonorrhoeae | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria meningitidis | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Klebsiella pneumoniae | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Azotobacter vinelandii | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Yersinia pestis | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Porphyromonas gingivalis | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio cholerae serotype O1 | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| deamino-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio alginolyticus | deamino-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Haemophilus influenzae | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Vibrio harveyi | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Pseudomonas aeruginosa | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Neisseria gonorrhoeae | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Neisseria meningitidis | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Klebsiella pneumoniae | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Azotobacter vinelandii | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Yersinia pestis | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Porphyromonas gingivalis | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Vibrio cholerae serotype O1 | ? | - |
? | |
| additional information | in addition to the quinone reductase reaction, the isolated enzyme can also catalyze the so-called NADH-dehydrogenase reaction during interaction with soluble quinones. This activity includes a single-electron reduction of soluble quinones (menadione, Q0, Q1, etc.) or some other electron acceptors (hexaammineruthenium (III), ferricyanide, etc.) | Vibrio alginolyticus | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Haemophilus influenzae | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Vibrio harveyi | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Pseudomonas aeruginosa | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Neisseria gonorrhoeae | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Neisseria meningitidis | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Klebsiella pneumoniae | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Azotobacter vinelandii | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Yersinia pestis | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Porphyromonas gingivalis | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Vibrio cholerae serotype O1 | ? | - |
? | |
| additional information | Na+-NQR does not oxidize NADPH | Vibrio alginolyticus | ? | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Haemophilus influenzae | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio harveyi | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Pseudomonas aeruginosa | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria gonorrhoeae | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria meningitidis | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Klebsiella pneumoniae | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Azotobacter vinelandii | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Yersinia pestis | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Porphyromonas gingivalis | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio cholerae serotype O1 | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio alginolyticus | NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Haemophilus influenzae | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio harveyi | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Pseudomonas aeruginosa | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria gonorrhoeae | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Neisseria meningitidis | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Klebsiella pneumoniae | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Azotobacter vinelandii | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Yersinia pestis | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Porphyromonas gingivalis | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio cholerae serotype O1 | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
| thio-NADH + H+ + ubiquinone + 2 Na+/in | - |
Vibrio alginolyticus | thio-NAD+ + ubiquinol + 2 Na+/out | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterohexamer | 1 * 48400 + 1 * 45400 + 1 * 27500 + 1 * 22700 + 1 * 21500 + 1 * 45200, calculated from amino acid sequence | Vibrio harveyi |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na+-NQR | - |
Haemophilus influenzae |
| Na+-NQR | - |
Vibrio harveyi |
| Na+-NQR | - |
Pseudomonas aeruginosa |
| Na+-NQR | - |
Neisseria gonorrhoeae |
| Na+-NQR | - |
Neisseria meningitidis |
| Na+-NQR | - |
Klebsiella pneumoniae |
| Na+-NQR | - |
Azotobacter vinelandii |
| Na+-NQR | - |
Yersinia pestis |
| Na+-NQR | - |
Porphyromonas gingivalis |
| Na+-NQR | - |
Vibrio cholerae serotype O1 |
| Na+-NQR | - |
Vibrio alginolyticus |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Haemophilus influenzae |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Vibrio harveyi |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Pseudomonas aeruginosa |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Neisseria gonorrhoeae |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Neisseria meningitidis |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Klebsiella pneumoniae |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Azotobacter vinelandii |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Yersinia pestis |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Porphyromonas gingivalis |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Vibrio cholerae serotype O1 |
| Na+-translocating NADH:ubiquinone oxidoreductase | - |
Vibrio alginolyticus |
| sodium-translocating NADH:quinone oxidoreductase | - |
Haemophilus influenzae |
| sodium-translocating NADH:quinone oxidoreductase | - |
Vibrio harveyi |
| sodium-translocating NADH:quinone oxidoreductase | - |
Pseudomonas aeruginosa |
| sodium-translocating NADH:quinone oxidoreductase | - |
Neisseria gonorrhoeae |
| sodium-translocating NADH:quinone oxidoreductase | - |
Neisseria meningitidis |
| sodium-translocating NADH:quinone oxidoreductase | - |
Klebsiella pneumoniae |
| sodium-translocating NADH:quinone oxidoreductase | - |
Azotobacter vinelandii |
| sodium-translocating NADH:quinone oxidoreductase | - |
Yersinia pestis |
| sodium-translocating NADH:quinone oxidoreductase | - |
Porphyromonas gingivalis |
| sodium-translocating NADH:quinone oxidoreductase | - |
Vibrio cholerae serotype O1 |
| sodium-translocating NADH:quinone oxidoreductase | - |
Vibrio alginolyticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Haemophilus influenzae | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Vibrio harveyi | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Pseudomonas aeruginosa | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Neisseria gonorrhoeae | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Neisseria meningitidis | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Klebsiella pneumoniae | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Azotobacter vinelandii | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Yersinia pestis | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Porphyromonas gingivalis | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Vibrio cholerae serotype O1 | |
| FAD | noncovalently bound to the NqrF subunit of Na+-NQR | Vibrio alginolyticus | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Haemophilus influenzae | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Vibrio harveyi | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Pseudomonas aeruginosa | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Neisseria gonorrhoeae | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Neisseria meningitidis | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Klebsiella pneumoniae | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Azotobacter vinelandii | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Yersinia pestis | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Porphyromonas gingivalis | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Vibrio cholerae serotype O1 | |
| FMN | covalently bound to the NqrB and NqrC subunits of Na+-NQR | Vibrio alginolyticus | |
| NADH | Na+-NQR is specific to NADH | Haemophilus influenzae | |
| NADH | Na+-NQR is specific to NADH | Vibrio harveyi | |
| NADH | Na+-NQR is specific to NADH | Pseudomonas aeruginosa | |
| NADH | Na+-NQR is specific to NADH | Neisseria gonorrhoeae | |
| NADH | Na+-NQR is specific to NADH | Neisseria meningitidis | |
| NADH | Na+-NQR is specific to NADH | Klebsiella pneumoniae | |
| NADH | Na+-NQR is specific to NADH | Azotobacter vinelandii | |
| NADH | Na+-NQR is specific to NADH | Yersinia pestis | |
| NADH | Na+-NQR is specific to NADH | Porphyromonas gingivalis | |
| NADH | Na+-NQR is specific to NADH | Vibrio cholerae serotype O1 | |
| NADH | Na+-NQR is specific to NADH | Vibrio alginolyticus | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Haemophilus influenzae | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Vibrio harveyi | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Pseudomonas aeruginosa | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Neisseria gonorrhoeae | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Neisseria meningitidis | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Klebsiella pneumoniae | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Azotobacter vinelandii | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Yersinia pestis | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Porphyromonas gingivalis | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Vibrio cholerae serotype O1 | |
| riboflavin | the enzyme contains one noncovalently bound riboflavin | Vibrio alginolyticus | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Haemophilus influenzae | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Vibrio harveyi | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Pseudomonas aeruginosa | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Neisseria gonorrhoeae | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Neisseria meningitidis | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Klebsiella pneumoniae | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Azotobacter vinelandii | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Yersinia pestis | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Porphyromonas gingivalis | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Vibrio cholerae serotype O1 | |
| ubiquinone-8 | the enzyme contains one ubiquinone-8 | Vibrio alginolyticus | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Haemophilus influenzae | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Vibrio harveyi | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Pseudomonas aeruginosa | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Neisseria gonorrhoeae | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Neisseria meningitidis | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Klebsiella pneumoniae | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Azotobacter vinelandii | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Yersinia pestis | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Porphyromonas gingivalis | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Vibrio cholerae serotype O1 | |
| [2Fe-2S]-center | part of the NqrF subunit of Na+-NQR | Vibrio alginolyticus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
