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Literature summary for 7.2.1.1 extracted from

  • Pfenninger-Li, X.D.; Albracht, S.P.J.; van Belzen, R.; Dimroth, P.
    NADH:ubiquinone oxidoreductase of Vibrio alginolyticus: Purification, properties, and reconstitution of the Na+ pump (1996), Biochemistry, 35, 6233-6242.
    View publication on PubMed
Search for more literature for 7.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
NADH incubation of the aerobic enzyme with NADH in the absence of an electron acceptor, the enzyme is destroyed with a half-inactivation time of about 2 min Vibrio alginolyticus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Vibrio alginolyticus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron an Fe-S-cluster of the [2Fe-2S] type is involved in electron translocation Vibrio alginolyticus
Na+ activates Vibrio alginolyticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + ubiquinone Vibrio alginolyticus the enzyme functions as a primary Na+ pump ?
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio alginolyticus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Vibrio alginolyticus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Vibrio alginolyticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + 2-methylnaphthoquinone
-
 Vibrio alginolyticus NAD+ + 2-methylnaphthalene-1,4-diol
-
 ?
NADH + ubiquinone
-
 Vibrio alginolyticus NAD+ + ubiquinol
-
 ?
NADH + ubiquinone the enzyme functions as a primary Na+ pump Vibrio alginolyticus ?
-
 ?
NADH + ubiquinone-1 electron transfer to ubiquinone-1 involves the semiquinone radical as an intermediate Vibrio alginolyticus NAD+ + ubiquinol-1
-
 ?

Subunits

Subunits Comment Organism
More the enzyme consists of three different hydrophilic and probably three different hydrophobic subunits Vibrio alginolyticus

Cofactor

Cofactor Comment Organism Structure
FAD enzyme contains FAD Vibrio alginolyticus
NADH
-
 Vibrio alginolyticus