Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial membrane | - |
Trypanosoma brucei | 31966 | - |
mitochondrion | - |
Trypanosoma brucei | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 4 H+[side 1] | Trypanosoma brucei | - |
ADP + phosphate + 4 H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 4 H+[side 1] | - |
Trypanosoma brucei | ADP + phosphate + 4 H+[side 2] | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 40000, subunit ATPaseTb2, SDS-PAGE | Trypanosoma brucei |
Synonyms | Comment | Organism |
---|---|---|
ATPaseTb2 | subunit | Trypanosoma brucei |
FoF1-ATPase | - |
Trypanosoma brucei |
General Information | Comment | Organism |
---|---|---|
malfunction | silencing of subunit ATPase Tb2 inhibits cell growth by decreasing the mitochondrial membrane potential in bloodstream form of Trypanosoma brucei. Depletion of subunit ATPase Tb2 does not significantly alter ATP hydrolysis capabilities but affects cell growth, the mitochondrial membrane potential and FoF1-ATPase integrity in dyskinetoplastic Trypanosoma brucei evansi | Trypanosoma brucei |
metabolism | the enzyme energizes the inner mitochondrial membrane by coupling ATP hydrolysis with the exchange of ADP3- for ATP4- by the ATP/ADP carrier | Trypanosoma brucei |
physiological function | the membrane-bound ATPaseTb2 subunit is essential for maintaining normal growth and the mitochondrial membrane potential of dyskinetoplastic cells | Trypanosoma brucei |