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Literature summary for 7.1.2.2 extracted from

  • Gloger, C.; Born, A.K.; Antosch, M.; Müller, V.
    The a subunit of the A1AO ATP synthase of Methanosarcina mazei Gö1 contains two conserved arginine residues that are crucial for ATP synthesis (2015), Biochim. Biophys. Acta, 1847, 505-513.
    View publication on PubMed
Search for more literature for 7.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
A1AO ATP synthase is functionally produced in the F1FO ATP synthase-negative strain Escherichia coli DK8 Methanosarcina mazei

Protein Variants

Protein Variants Comment Organism
R563A mutation in the a subunit leads to total loss of ATP synthesis activity Methanosarcina mazei
R563A/R625A mutation in the a subunit leads to total loss of ATP synthesis activity Methanosarcina mazei
R563K mutation in the a subunit leads to total loss of ATP synthesis activity Methanosarcina mazei
R563K/R625K mutation in the a subunit leads to total loss of ATP synthesis activity Methanosarcina mazei
R625A mutation in the a subunit leads to total loss of ATP synthesis activity Methanosarcina mazei
R625K mutation in the a subunit, almost 50% of the ATP synthesis activity is retained compared to the wild type enzyme Methanosarcina mazei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Methanosarcina mazei
-
 ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in Methanosarcina mazei DSM 3647
-
 ADP + phosphate + H+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Methanosarcina mazei
-
-
-
Methanosarcina mazei DSM 3647
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Methanosarcina mazei ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in the function of the ATP synthase is analyzed in an inverted membrane vesicle system of Escherichia coli DK8 Methanosarcina mazei ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in
-
 Methanosarcina mazei DSM 3647 ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in the function of the ATP synthase is analyzed in an inverted membrane vesicle system of Escherichia coli DK8 Methanosarcina mazei DSM 3647 ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
A1AO ATP synthase
-
 Methanosarcina mazei