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Literature summary for 7.1.2.2 extracted from

  • Giorgio, V.; Bisetto, E.; Soriano, M.E.; Dabbeni-Sala, F.; Basso, E.; Petronilli, V.; Forte, M.A.; Bernardi, P.; Lippe, G.
    Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex (2009), J. Biol. Chem., 284, 33982-33988.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.2

Activating Compound

Activating Compound Comment Organism Structure
cyclosporin A cyclosporin A stimulates both ATP hydrolysis and synthesis, and displaces cyclophilin D from MgATP-submitochondrial particles Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
cyclophilin D cyclophilin D associates to the FOF1-ATP synthase complex in bovine heart mitochondria. The ATP synthase-cyclophilin D interactions have functional consequences on enzyme catalysis and are modulated by phosphate, leading to increased CyPD binding and decreased enzyme activity, and by cyclosporin A, leading to decreased CyPD binding and increased enzyme activity Bos taurus
oligomycin
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Bos taurus 31966
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Bos taurus
-
 ADP + phosphate + H+/out
-
 r
additional information Bos taurus cyclophilin D associates to the F0F1-ATP synthase complex in bovine heart mitochondria. The ATP synthase-CyPD interactions have functional consequences on enzyme catalysis and are modulated by phosphate, leading to increased CyPD binding and decreased enzyme activity, and by cyclosporin A, leading to decreased CyPD binding and increased enzyme activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Bos taurus ADP + phosphate + H+/out
-
 r
additional information cyclophilin D associates to the F0F1-ATP synthase complex in bovine heart mitochondria. The ATP synthase-CyPD interactions have functional consequences on enzyme catalysis and are modulated by phosphate, leading to increased CyPD binding and decreased enzyme activity, and by cyclosporin A, leading to decreased CyPD binding and increased enzyme activity Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
F0F1-ATP synthase
-
 Bos taurus
mitochondrial F0F1-ATP synthase
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 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 ATP synthase assay at Bos taurus
37
-
 ATP hydrolysis assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bos taurus