Literature summary for 7.1.2.2 extracted from

Giorgio, V.; Bisetto, E.; Franca, R.; Harris, D.A.; Passamonti, S.; Lippe, G.
The ectopic FoF1 ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1 (2010), J. Bioenerg. Biomembr., 42, 117-123.

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Inhibitors

Inhibitors	Comment	Organism	Structure
inhibitor protein IF1	F1 in mitochondria is associated with a small regulatory protein, IF1, which inhibits its ATPase activity and the ecto-FOF1 activity, overview	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	mitochondrial FOF1 ATP synthase	Rattus norvegicus	5739	-
plasma membrane	ectopic FOF1 ATP synthase complexes	Rattus norvegicus	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ADP + phosphate + H+/out	Rattus norvegicus	-	ATP + H2O + H+/in	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
native enzymes from plasma membranes and mitochondria, solubilization by Triton X-100	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + phosphate + H+/out	-	Rattus norvegicus	ATP + H2O + H+/in	-	?

Synonyms

Synonyms	Comment	Organism
ectopic FoF1 ATP synthase	-	Rattus norvegicus
mitochondrial FOF1 ATP synthase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	the aurovertin B-sensitive ATPase activity of ecto-FOF1 is markedly inhibited in cholestatic rats, to about 45% of that from control rats	Rattus norvegicus

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Release 2023.1 (January 2023)