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Literature summary for 7.1.2.2 extracted from

  • Radojkovic, C.; Genoux, A.; Pons, V.; Combes, G.; de Jonge, H.; Champagne, E.; Rolland, C.; Perret, B.; Collet, X.; Terce, F.; Martinez, L.O.
    Stimulation of cell surface F1-ATPase activity by apolipoprotein A-I inhibits endothelial cell apoptosis and promotes proliferation (2009), Arterioscler. Thromb. Vasc. Biol., 29, 1125-1130.
    View publication on PubMed
Search for more literature for 7.1.2.2

Activating Compound

Activating Compound Comment Organism Structure
apoA-I the enzyme binds apoA-I which activates the ATPase activity. The antiapoptotic and proliferative effects of apoA-I on HUVECs are totally blocked by the F1-ATPase ligands IF1-H49K, angiostatin and anti-F1-ATPase antibody, independently of the scavenger receptor SR-BI and ABCA1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
IF1 protein the ability of IF1 to inhibit F1-ATPase activity depends on pH with a better efficiency at pH below 6.5 Homo sapiens
IF1-H49K protein the F1-ATpase specific inhibitor inhibits the ATPase activity, the IF1 mutant shows inhibitory activity at neutral pH Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Homo sapiens 9986
-
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Homo sapiens
-
 ADP + phosphate + H+/out
-
 ?
additional information Homo sapiens the cell surface F1-ATPase pathway may contribute to the antiapoptotic and proliferative effects mediated by apoA-I and HDLs on endothelial cells. The antiapoptotic and proliferative effects of apoA-I on HUVECs are totally blocked by the F1-ATPase ligands IF1-H49K, angiostatin and anti-F1-ATPase antibody, independently of the scavenger receptor SR-BI and ABCA1, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Homo sapiens ADP + phosphate + H+/out
-
 ?
additional information the cell surface F1-ATPase pathway may contribute to the antiapoptotic and proliferative effects mediated by apoA-I and HDLs on endothelial cells. The antiapoptotic and proliferative effects of apoA-I on HUVECs are totally blocked by the F1-ATPase ligands IF1-H49K, angiostatin and anti-F1-ATPase antibody, independently of the scavenger receptor SR-BI and ABCA1, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
F1-ATPase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens