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Literature summary for 7.1.2.2 extracted from

  • Di Pancrazio, F.; Mavelli, I.; Isola, M.; Losano, G.; Pagliaro, P.; Harris, D.A.; Lippe, G.
    In vitro and in vivo studies of F(0)F(1)ATP synthase regulation by inhibitor protein IF(1) in goat heart (2004), Biochim. Biophys. Acta, 1659, 52-62.
    View publication on PubMed

Application

Application Comment Organism
medicine when hyperemia is induced before ischemic preconditioning, a steep increase in synthase capacity, followed by a deep decrease can be observed, hyperemia does not affect synthase capacity when applied after ischemic preconditioning, similar effects in vitro by treatment of heart biopsy samples with anoxia, which down-regulates, or high salt or high pH buffers, which up-regulates Capra hircus

Inhibitors

Inhibitors Comment Organism Structure
regulatory protein IF1 the only significant modulator of enzyme activity, 1300-1400 mM of IF1 is predicted to fully inactivate 1000 mM of synthase, both in vivo and in vitro, thus excluding significant binding numbers of non-inhibitory binding sites for IF1 in the F0 sector Capra hircus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Capra hircus 5739
-

Organism

Organism UniProt Comment Textmining
Capra hircus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Capra hircus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
Capra hircus ADP + phosphate + H+/out
-
r

Synonyms

Synonyms Comment Organism
F0F1ATP synthase
-
Capra hircus