Application | Comment | Organism |
---|---|---|
medicine | myocardial CcOX impairment can underlie CO induced cardiac dysfunction | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO | significantly decreases myocardial CcOX activity. CcOX I protein levels significantly decrease following CO exposure while enzyme turnover number and CcOX I mRNA levels remain unchanged. Decreased CcOX activity following CO inhalation is likely due to decreased heme aa3 and CcOX subunit I content | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.037 | - |
ferrocytochrome c | following sham exposure | Mus musculus | |
0.041 | - |
ferrocytochrome c | following CO exposure | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male C57Bl6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart ventricle | - |
Mus musculus | - |
myocardium | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ferrocytochrome c + O2 + H+ | - |
Mus musculus | ferricytochrome c + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CcOX | - |
Mus musculus |
cytochrome oxidase | - |
Mus musculus |