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Literature summary for 7.1.1.9 extracted from

  • Lee, I.; Salomon, A.R.; Ficarro, S.; Mathes, I.; Lottspeich, F.; Grossman, L.; Hüttemann, M.
    cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity (2005), J. Biol. Chem., 280, 6094-6110.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine at therapeutic concentrations used for asthma relief, theophylline causes inhibition of the lung enzyme and decreases cellular ATP levels, suggesting a mechanism for its clinical action Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
additional information cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity Bos taurus
theophylline at therapeutic concentrations used for asthma relief, theophylline causes inhibition of the lung enzyme and decreases cellular ATP levels, suggesting a mechanism for its clinical action Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ferrocytochrome c + O2 Bos taurus terminal enzyme of the electron transport chain. The glucagon receptor/G-protein/c-AMP pathway regulates enzyme activity ferricytochrome c + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2 terminal enzyme of the electron transport chain. The glucagon receptor/G-protein/c-AMP pathway regulates enzyme activity Bos taurus ferricytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
COX
-
 Bos taurus