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Literature summary for 7.1.1.9 extracted from

  • Tomson, F.L.; Morgan, J.E.; Gu, G.; Barquera, B.; Vygodina, T.V.; Gennis, R.B.
    Substitutions for glutamate 101 in subunit II of cytochrome c oxidase from Rhodobacter sphaeroides result in blocking the proton-conducting K-channel (2003), Biochemistry, 42, 1711-1717.
    View publication on PubMed
Search for more literature for 7.1.1.9

Protein Variants

Protein Variants Comment Organism
E101A mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
E101C mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
E101D mutation in subunit II strongly reduces oxidase activity to 16% Cereibacter sphaeroides
E101H mutation in subunit II strongly reduces oxidase activity to 19% Cereibacter sphaeroides
E101I mutation in subunit II strongly reduces oxidase activity to 8% Cereibacter sphaeroides
E101N mutation in subunit II strongly reduces oxidase activity to 17% Cereibacter sphaeroides
E101Q mutation in subunit II strongly reduces oxidase activity to 14% Cereibacter sphaeroides
H300A mutation in subunit I increases oxidase activity to 111% Cereibacter sphaeroides
K362M enzyme with mutation in subunit I is inactive Cereibacter sphaeroides
L100AV mutation in subunit II increases oxidase turnover to 45% Cereibacter sphaeroides
S299A mutation in subunit I reduces oxidase activity to 45% Cereibacter sphaeroides
W104V mutation in subunit II reduces oxidase activity to 45% Cereibacter sphaeroides
W105A mutation in subunit II reduces oxidase activity to 50% Cereibacter sphaeroides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cereibacter sphaeroides the predominant entry point for protons going into the K-channel of cytochrome oxidase is the surface-exposed glutamic acid E101 in subunit II ?
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 ?

Organism

Organism UniProt Comment Textmining
Cereibacter sphaeroides
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2
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 Cereibacter sphaeroides ferricytochrome c + H2O
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 ?
additional information the predominant entry point for protons going into the K-channel of cytochrome oxidase is the surface-exposed glutamic acid E101 in subunit II Cereibacter sphaeroides ?
-
 ?