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Literature summary for 7.1.1.8 extracted from

  • Siregar, J.E.; Kurisu, G.; Kobayashi, T.; Matsuzaki, M.; Sakamoto, K.; Mi-ichi, F.; Watanabe, Y.; Hirai, M.; Matsuoka, H.; Syafruddin, D.; Marzuki, S.; Kita, K.
    Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex (2015), Parasitol. Int., 64, 295-300 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-n-heptyl-6-hydroxy-4,7-dioxobenzothiazole
-
Plasmodium berghei
atovaquone
-
Plasmodium berghei
Stigmatellin
-
Plasmodium berghei

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-
Plasmodium berghei ANKA
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquinol + ferricytochrome c
-
Plasmodium berghei ubiquinone + ferrocytochrome c + H+
-
?
ubiquinol + ferricytochrome c
-
Plasmodium berghei ANKA ubiquinone + ferrocytochrome c + H+
-
?

Synonyms

Synonyms Comment Organism
cytochrome bc1 complex
-
Plasmodium berghei
ubiquinol-cytochrome c reductase
-
Plasmodium berghei

Cofactor

Cofactor Comment Organism Structure
cytochrome c
-
Plasmodium berghei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000327
-
at pH 8.0 and 25°C Plasmodium berghei atovaquone