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Literature summary for 7.1.1.8 extracted from
- Development of a novel class of mitochondrial ubiquinol-cytochrome c reductase binding protein (UQCRB) modulators as promising antiangiogenic leads (2014), J. Med. Chem., 57, 7990-7998 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-ethyl-N-(4-hydroxyphenyl)benzenesulfonamide | - |
Homo sapiens |  |
| 4-tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide | - |
Homo sapiens | |
| 4-tert-butyl-N-(3-hydroxyphenyl)benzenesulfonamide | - |
Homo sapiens | |
| 4-tert-butyl-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide | - |
Homo sapiens | |
| 4-tert-butyl-N-(4-hydroxyphenyl)benzenesulfonamide | - |
Homo sapiens | |
| 4-tert-butyl-N-(8-hydroxyquinolin-5-yl)benzenesulfonamide | - |
Homo sapiens | |
| 5-(biphenyl-4-ylsulfonamido)-2-hydroxybenzoic acid | - |
Homo sapiens | |
| 6-((1-hydroxynaphthalen-4-ylamino)dioxysulfone)-2H-naphtho[1,8-bc]thiophen-2-one | - |
Homo sapiens | |
| N-(3-chloro-4-hydroxyphenyl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(3-fluoro-4-hydroxyphenyl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(4-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide | - |
Homo sapiens | |
| N-(4-hydroxyphenyl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(4-hydroxyphenyl)naphthalene-2-sulfonamide | - |
Homo sapiens | |
| N-(4-hydroxyphenyl)quinoline-8-sulfonamide | - |
Homo sapiens | |
| N-(5-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(7-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| N-(8-hydroxyquinolin-5-yl)biphenyl-4-sulfonamide | - |
Homo sapiens | |
| potassium 4-(biphenyl-4-ylsulfonamido)phenolate | - |
Homo sapiens | |
| terpestacin | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinol + 2 ferricytochrome c | Homo sapiens | - |
quinone + 2 ferrocytochrome c + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HUVEC cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| quinol + 2 ferricytochrome c | - |
Homo sapiens | quinone + 2 ferrocytochrome c + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ubiquinol-cytochrome c reductase binding protein | - |
Homo sapiens |
| UQCRB | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome c | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0025 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(4-hydroxyphenyl)biphenyl-4-sulfonamide | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(4-hydroxyphenyl)benzenesulfonamide | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | potassium 4-(biphenyl-4-ylsulfonamido)phenolate | |
| 0.005 | - |
pH and temperature not specified in the publication | Homo sapiens | 6-((1-hydroxynaphthalen-4-ylamino)dioxysulfone)-2H-naphtho[1,8-bc]thiophen-2-one | |
| 0.008 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(2-hydroxyphenyl)benzenesulfonamide | |
| 0.02 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(4-hydroxynaphthalen-1-yl)benzenesulfonamide | |
| 0.02 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(8-hydroxyquinolin-5-yl)benzenesulfonamide | |
| 0.02 | - |
pH and temperature not specified in the publication | Homo sapiens | N-(8-hydroxyquinolin-5-yl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | 4-ethyl-N-(4-hydroxyphenyl)benzenesulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(3-fluoro-4-hydroxyphenyl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(3-chloro-4-hydroxyphenyl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | 5-(biphenyl-4-ylsulfonamido)-2-hydroxybenzoic acid | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(4-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(5-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(7-hydroxynaphthalen-1-yl)biphenyl-4-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(4-hydroxyphenyl)naphthalene-2-sulfonamide | |
| 0.02 | - |
IC50 above 0.02 mM, pH and temperature not specified in the publication | Homo sapiens | N-(4-hydroxyphenyl)quinoline-8-sulfonamide | |
| 0.098 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-tert-butyl-N-(3-hydroxyphenyl)benzenesulfonamide | |
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