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Literature summary for 7.1.1.8 extracted from
- Antimycin resistance and ubiquinol cytochrome c reductase instability associated with a human cytochrome b mutation (1996), Biochim. Biophys. Acta, 1317, 199-209.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | complex III deficiency in the muscle mitochondria | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Myxothiazol | - |
Bos taurus |  |
| Myxothiazol | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
ubiquinol | - |
Homo sapiens | |
| 0.004 | - |
2 ferricytochrome c | patient with cytochrome b mutation | Homo sapiens | |
| 0.009 | - |
2 ferricytochrome c | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 9500 | - |
- |
Homo sapiens |
| 9500 | - |
- |
Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Homo sapiens | - |
human | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Homo sapiens | - |
| heart | - |
Bos taurus | - |
| muscle | - |
Homo sapiens | - |
| muscle | - |
Bos taurus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -80°C | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ubiquinol + 2 ferricytochrome c | - |
Homo sapiens | ubiquinone + 2 ferrocytochrome c + 2 H+ | - |
? | |
| ubiquinol + 2 ferricytochrome c | - |
Bos taurus | ubiquinone + 2 ferrocytochrome c + 2 H+ | - |
? | |
| ubiquinol + 2 ferricytochrome c | - |
Homo sapiens | ubiquinone + 2 ferrocytochrome c + 2 H+[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| undecamer | - |
Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
stable at 37°C, progressively decreases at 4°C | Homo sapiens |
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Release 2023.1 (January 2023)
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