Cloned (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
crystal structures of apoprotein an in complex with NADH and inhibitor 5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one | inhibitor exhibits potency against both drug-resistant strains in vitro and parasite-infected mice in vivo via a potential allosteric mechanism. Inhibitor can be used in combination with dihydroartemisinin synergistically | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0349 | - |
ubiquinone-1 | pH 7.0, 25°C | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8I302 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + ubiquinone-1 + 5 H+[side 1] | - |
Plasmodium falciparum | NAD+ + ubiquinol-1 + 4 H+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PF3D7_0915000 | - |
Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
664 | - |
ubiquinone-1 | pH 7.0, 25°C | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000037 | - |
pH 7.0, 25°C | Plasmodium falciparum | 5-fluoro-3-methyl-2-(4-(4-(trifluoromethoxy)benzyl)-phenyl)quinolin-4(1H)-one |