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Literature summary for 7.1.1.2 extracted from

  • Euro, L.; Belevich, G.; Verkhovsky, M.I.; Wikstroem, M.; Verkhovskaya, M.
    Conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase (Complex I) (2008), Biochim. Biophys. Acta, 1777, 1166-1172.
    View publication on PubMed
Search for more literature for 7.1.1.2

Protein Variants

Protein Variants Comment Organism
E144A mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
E144D mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
E144D mutation in subunit NuoM, quinone reductase activity is unchanged Escherichia coli
K234A mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
K234R mutation in subunit NuoM, quinone reductase activity is lost Escherichia coli
K265A mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
K265A mutation in subunit NuoM, quinone reductase activity is decreased Escherichia coli
W243A mutation in subunit NuoM, mutant has wild type sensitivity to rolliniastatin and complete proton-pumping efficiency of complex I Escherichia coli
W243A mutation in subunit NuoM, quinone reductase activity is decreased Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
rolliniastatin
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase Escherichia coli 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + ubiquinone Escherichia coli conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase NAD+ + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + decylubiquinone
-
 Escherichia coli NAD+ + decylubiquinol
-
 ?
NADH + H+ + ubiquinone conserved lysine residues of the membrane subunit NuoM are involved in energy conversion by the proton-pumping NADH:ubiquinone oxidoreductase Escherichia coli NAD+ + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Escherichia coli
proton-pumping NADH:ubiquinone oxidoreductase
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Escherichia coli