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Literature summary for 7.1.1.2 extracted from

  • Ben-Shachar, D.; Bonne, O.; Chisin, R.; Klein, E.; Lester, H.; Aharon-Peretz, J.; Yona, I.; Freedman, N.
    Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study (2007), Prog. Neuropsychopharmacol. Biol. Psychiatry, 31, 807-813.
    View publication on PubMed
Search for more literature for 7.1.1.2

Application

Application Comment Organism
medicine correlation between peripheral complex I activity and cerebral glucose metabolism in regions implicated in schizophrenia, may be a pathological factor that is differentially expressed in subgroups of schizophrenic patients Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
basal ganglion in the high positive schizophrenic group a positive correlation exists between cerebral glucose metabolism and complex I activity in the basal ganglia (lentiform nucleus including the putamen and globus pallidus) and the thalamus, but reaches significance only for its left side Homo sapiens
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blood platelet complex I activity is significantly higher in high positive schizophrenics as compared to control subjects and low positive schizophrenic patients. In low positive schizophrenic patients complex I activity does not differ from that of the control group. Entering age and gender as covariates has no effect on the significance of difference in complex I activity between subject groups. Significant positive correlation between complex I activity and the severity of positive symptoms Homo sapiens
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brain stem in the low positive schizophrenic group, a region of negative correlation between cerebral glucose metabolism and complex I activity is identified bilaterally in the cerebellum and brainstem Homo sapiens
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cerebellum in the low positive schizophrenic group, a region of negative correlation between cerebral glucose metabolism and complex I activity is identified bilaterally in the cerebellum and brainstem Homo sapiens
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additional information in the control group, no areas of significant positive or negative correlation between cerebral glucose metabolism and peripheral complex I activity exist Homo sapiens
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thalamus in the high positive schizophrenic group a positive correlation exists between cerebral glucose metabolism and complex I activity in the basal ganglia (lentiform nucleus including the putamen and globus pallidus) and the thalamus, but reaches significance only for its left side Homo sapiens
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Synonyms

Synonyms Comment Organism
complex I
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 Homo sapiens
NADH CoQ reductase
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 Homo sapiens