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Literature summary for 7.1.1.2 extracted from

  • Watabe, M.; Nakaki, T.
    Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells (2007), J. Pharmacol. Exp. Ther., 323, 499-507.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
rotenone inhibits complex I followed by apoptosis. 40% decrease of dopamine content suppresses rotenone-induced apoptosis. 30% increase of dopamine content by inhibition of dopamine metabolism enhances rotenone-induced apoptosis. Depletion of intracellular dopamine using reserpine (0.0001-0.01 mM) also prevents rotenone-induced apoptosis, and this effect is counteracted by dopamine (0.01-0.1 mM) replenishment. Inhibition of dopamine reverse transport increases cytosolic dopamine and enhances rotenone-induced apoptosis. Rotenone induces dopamine redistribution from vesicles to the cytosol. Rotenone stimulates reactive oxygen species and protein carbonylation and decreases the antioxidant glutathione. Addition of the antioxidant N-acetylcysteine (3 mM), prevents dopamine being expelled from vesicles and inhibits rotenone-induced apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
complex I
-
Homo sapiens