Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rotenone | inhibits complex I followed by apoptosis. 40% decrease of dopamine content suppresses rotenone-induced apoptosis. 30% increase of dopamine content by inhibition of dopamine metabolism enhances rotenone-induced apoptosis. Depletion of intracellular dopamine using reserpine (0.0001-0.01 mM) also prevents rotenone-induced apoptosis, and this effect is counteracted by dopamine (0.01-0.1 mM) replenishment. Inhibition of dopamine reverse transport increases cytosolic dopamine and enhances rotenone-induced apoptosis. Rotenone induces dopamine redistribution from vesicles to the cytosol. Rotenone stimulates reactive oxygen species and protein carbonylation and decreases the antioxidant glutathione. Addition of the antioxidant N-acetylcysteine (3 mM), prevents dopamine being expelled from vesicles and inhibits rotenone-induced apoptosis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-SY5Y cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Homo sapiens |