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Literature summary for 7.1.1.2 extracted from

  • Yadava, N.; Nicholls, D.G.
    Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone (2007), J. Neurosci., 27, 7310-7317.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine partial inhibition of mitochondrial respiratory complex I by rotenone reproduces aspects of Parkinson’s disease in rodents. Cell vulnerability in the rotenone model of partial complex I deficiency is primarily determined by spare respiratory capacity rather than oxidative stress Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
rotenone
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 5-7 days old Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information cerebellar granule neuron Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
complex I
-
 Rattus norvegicus
NADH-ubiquinone oxidoreductase
-
 Rattus norvegicus
nicotinamide adenine dinucleotide-ubiquinone oxidoreductase
-
 Rattus norvegicus