Literature summary for 7.1.1.2 extracted from

Li, Y.; DAurelio, M.; Deng, J.H.; Park, J.S.; Manfredi, G.; Hu, P.; Lu, J.; Bai, Y.
An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria (2007), J. Biol. Chem., 282, 17557-17562.

Search for more literature for 7.1.1.2

Application

Application	Comment	Organism
additional information	an assembled complex IV helps to maintain complex I in mammalian cells	Mus musculus
additional information	an assembled complex IV helps to maintain complex I in mammalian cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	COX I mutant cybrids show a 80% reduction in complex I enzymatic activity in isolated mitochondria as compared with control cybrids	Homo sapiens
additional information	mouse cell lines with suppressed expression of the nuclearly encoded subunit 4 of complex IV associated with a loss of assembly of complex IV show significantly reduced level of assembled complex I and activity, whereas levels and activity of complex III are normal or up-regulated	Mus musculus
rotenone	completely obstructs electron transfer through complex I	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-9 cell	-	Mus musculus	-
additional information	transmitochondrial cell line, cybrids from a patient with a multisystem mitochondrial disorder with a G6930A nonsense mutation in the COX I gene. G6930A mutation causes a disruption in the assembly and defective activity of complex VI	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ubiquinone + NADH + H+	-	Mus musculus	ubiquinol + NAD+	-	?

Synonyms

Synonyms	Comment	Organism
complex I	-	Mus musculus
complex I	-	Homo sapiens
NADH-ubiquinone oxidoreductase	-	Mus musculus
NADH-ubiquinone oxidoreductase	-	Homo sapiens

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Release 2023.1 (January 2023)