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Literature summary for 7.1.1.2 extracted from

  • Wani, A.A.; Rangrez, A.Y.; Kumar, H.; Bapat, S.A.; Suresh, C.G.; Barnabas, S.; Patole, M.S.; Shouche, Y.S.
    Analysis of reactive oxygen species and antioxidant defenses in complex I deficient patients revealed a specific increase in superoxide dismutase activity (2008), Free Radic. Res., 42, 415-427.
    View publication on PubMed

Application

Application Comment Organism
medicine complex I deficient patients show a specific increase in superoxide dismutase activity. Reactive oxygen species production remains significantly elevated in complex I deficient patients compared to controls, whereas glutathione peroxidase, catalase and glutathione-S-transferase are significantly reduced. Information on the status of reactive oxygen species and marking the alteration of reactive oxygen species scavenging enzymes in peripheral lymphocytes or lymphoblast cell lines will provide a better way to design antioxidant therapies for such disorders like complex I deficiency Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
complex I
-
Homo sapiens
NADH dehydrogenase
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Homo sapiens