Activating Compound | Comment | Organism | Structure |
---|---|---|---|
malate | - |
Homo sapiens | |
malate | when RCC-I is activated, mitochondrial superoxide is decreased by mitochondrial nitric oxide synthase stimulation, whereas decreased superoxide is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I activation increases mitochondrial S-nitrosoglutathione that is further increased by mitochondrial nitric oxide synthase stimulation and prevented when mitochondrial nitric oxide synthase is inhibited | Rattus norvegicus | |
pyruvate | - |
Homo sapiens | |
pyruvate | when RCC-I is activated, mitochondrial superoxide is decreased by mitochondrial nitric oxide synthase stimulation, whereas decreased superoxide is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I activation increases mitochondrial S-nitrosoglutathione that is further increased by mitochondrial nitric oxide synthase stimulation and prevented when mitochondrial nitric oxide synthase is inhibited | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | crucial role for mitochondrial nitric oxide synthase in oxidative stress caused by mitochondrial complex I inactivation | Homo sapiens |
additional information | crucial role for mitochondrial nitric oxide synthase in oxidative stress caused by mitochondrial complex I inactivation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rotenone | RCC-I inactivation causes a dramatic decrease in mitochondrial NO that is not affected by Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. RCC-I inactivation drastically increases mitochondrial reactive oxygen species, which is prevented when mitochondrial nitric oxide synthase is inhibited or cells are treated with Mn (III) porphyrin 5,10,15,20-tetrakis(benzoic acid) porphyrin. Inactivation of RCC-I in SHSY cells dramatically increases tyrosine nitration of mitochondrial proteins that is fully prevented when mitochondrial nitric oxide synthase is inactivated. RCC-I inactivation leads cytochrome c to diffuse into the cytoplasm indicating its release from the mitochondria | Homo sapiens | |
rotenone | when RCC-I is inactivated, mitochondrial nitric oxide synthase stimulation dramatically augments the superoxide signal, whereas augmented superoxide signal is prevented when mitochondrial nitric oxide synthase is inhibited and abolished by superoxide dismutase. RCC-I inactivation dramatically increases S-nitrosoglutathione decomposition that is prevented when mitochondrial nitric oxide synthase is inhibited. RCC-I inactivation increases tyrosine-nitrated mitochondrial proteins, causes cytochrome c release and aggregation of mitochondria | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
SpragueDawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | SHSY cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
RCC-I | - |
Homo sapiens |
RCC-I | - |
Rattus norvegicus |
respiratory chain complex I | - |
Homo sapiens |
respiratory chain complex I | - |
Rattus norvegicus |