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Literature summary for 7.1.1.2 extracted from

  • Zmijewski, J.W.; Lorne, E.; Zhao, X.; Tsuruta, Y.; Sha, Y.; Liu, G.; Siegal, G.P.; Abraham, E.
    Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury (2008), Am. J. Respir. Crit. Care Med., 178, 168-179.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine mitochondrial complex I plays an important role in modulating Toll-like receptor 4-mediated neutrophil activation. Metformin, as well as other agents that inhibit mitochondrial complex I, may be useful in the prevention or treatment of acute inflammatory processes in which activated neutrophils play a major role, such as acute lung injury Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
metformin inhibits complex I activity, associated with LPS-induced neutrophil activation. Metformin prevents LPS-induced acute lung injury Mus musculus
rotenone inhibits complex I, which is associated with increased ROS generation, LPS-induced nuclear translocation of NF-kappaB and cytokine production in neutrophils. Rotenone pretreatment attenuates LPS-induced acute lung injury Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-
neutrophil
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + coenzyme Q1 + H+
-
Mus musculus NAD+ + reduced coenzyme Q1
-
?

Synonyms

Synonyms Comment Organism
complex I
-
Mus musculus