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Literature summary for 7.1.1.2 extracted from

  • Ichimaru, N.; Abe, M.; Murai, M.; Senoh, M.; Nishioka, T.; Miyoshi, H.
    Function of the alkyl side chains of Deltalac-acetogenins in the inhibitory effect on mitochondrial complex I (NADH-ubiquinone oxidoreductase) (2006), Bioorg. Med. Chem. Lett., 16, 3555-3558.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]-5-propylnonan-1-ol IC50: 870 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyethyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol IC50: 280 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]pentadecan-1-ol IC50: 34 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol IC50: 3.2 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxynonyl]octahydro-2,2'-bifuran-5-yl]tridecan-1-ol IC50: 7.5 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxypropyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol IC50: 45 nM Bos taurus
(1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-5-ethyl-1-hydroxyoctyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol IC50: 27 nM Bos taurus
(1R)-5-ethyl-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]octan-1-ol IC50: 1500 nM Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldihexan-1-ol IC50: 4500 nM Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldioctan-1-ol IC50: 45 nM Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol IC50: 1.6 nM Bos taurus
(1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol IC50: 9.0 nM Bos taurus
bullatacin potent inhibitor Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Bos taurus
NADH-ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000016
-
 IC50: 1.6 nM Bos taurus (1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldiundecan-1-ol
0.0000032
-
 IC50: 3.2 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
0.0000075
-
 IC50: 7.5 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxynonyl]octahydro-2,2'-bifuran-5-yl]tridecan-1-ol
0.000009
-
 IC50: 9.0 nM Bos taurus (1R,1'S)-1,1'-(2R,5R)-tetrahydrofuran-2,5-diylditridecan-1-ol
0.000027
-
 IC50: 27 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-5-ethyl-1-hydroxyoctyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
0.000034
-
 IC50: 34 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyheptyl]octahydro-2,2'-bifuran-5-yl]pentadecan-1-ol
0.000045
-
 IC50: 45 nM Bos taurus (1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldioctan-1-ol
0.000045
-
 IC50: 45 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxypropyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
0.00028
-
 IC50: 280 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxyethyl]octahydro-2,2'-bifuran-5-yl]undecan-1-ol
0.00087
-
 IC50: 870 nM Bos taurus (1R)-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]-5-propylnonan-1-ol
0.0015
-
 IC50: 1500 nM Bos taurus (1R)-5-ethyl-1-[(2R,2'R,5R,5'R)-5'-[(1R)-1-hydroxy-5-propyloctyl]octahydro-2,2'-bifuran-5-yl]octan-1-ol
0.0045
-
 IC50: 4500 nM Bos taurus (1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diyldihexan-1-ol