Literature summary for 7.1.1.2 extracted from

Friedrich, T.; Stolpe, S.; Schneider, D.; Barquera, B.; Hellwig, P.
Ion translocation by the Escherichia coli NADH:ubiquinone oxidoreductase (complex I) (2005), Biochem. Soc. Trans., 33, 836-839.

Search for more literature for 7.1.1.2

Inhibitors

Inhibitors	Comment	Organism	Structure
5-(N-ethyl)-N-isopropylamiloride	IC50 : 0.1 mM	Escherichia coli
benzamil	IC50: 0.07 mM	Escherichia coli
dicyclohexylcarbodi-imide	90% inhibition, IC50: 0.25 mM	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + decyl-ubiquinone	-	Escherichia coli	NAD+ + decyl-ubiquinol	-	?
NADH + ubiquinone	-	Escherichia coli	NAD+ + ubiquinol	-	?

Synonyms

Synonyms	Comment	Organism
NADH:ubiquinone oxidoreductase	-	Escherichia coli
respiratory complex I	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
NADH	-	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.07	-	IC50: 0.07 mM	Escherichia coli	benzamil
0.1	-	IC50 : 0.1 mM	Escherichia coli	5-(N-ethyl)-N-isopropylamiloride
0.25	-	90% inhibition, IC50: 0.25 mM	Escherichia coli	dicyclohexylcarbodi-imide

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Release 2023.1 (January 2023)