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Literature summary for 7.1.1.2 extracted from

  • Loskovich, M.V.; Grivennikova, V.G.; Cecchini, G.; Vinogradov, A.D.
    Inhibitory effect of palmitate on the mitochondrial NADH:ubiquinone oxidoreductase (complex I) as related to the active-de-active enzyme transition (2005), Biochem. J., 387, 677-683.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
palmitate IC50: 0.009 mM, at 25°C and pH 8.0 Bos taurus
piericidin the residual activity in the presence of saturating palmitate is completely (>90%) inhibited by piericidin Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + 2,3-dimethoxy-5-methyl-6-isoprenyl-1,4-benzoquinone
-
 Bos taurus NAD+ + ?
-
 ?
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Bos taurus
NADH:external quinone reductase
-
 Bos taurus
NADH:ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
 IC50: 0.009 mM, at 25°C and pH 8.0 Bos taurus palmitate