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Literature summary for 7.1.1.2 extracted from

  • Biagini, G.A.; Viriyavejakul, P.; Oneill, P.M.; Bray, P.G.; Ward, S.A.
    Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria (2006), Antimicrob. Agents Chemother., 50, 1841-1851.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
diphenyl iodonium chloride 0.001 mM and above Plasmodium falciparum
diphenylene iodonium chloride 0.001 mM and above Plasmodium falciparum
additional information insensitive to rotenone Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0051
-
 NADH using decylubiquinone as substrate Plasmodium falciparum
0.0167
-
 NADH using ubiquinone-1 as substrate Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Plasmodium falciparum 5739
-

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + decylubiquinone
-
 Plasmodium falciparum NAD+ + decylubiquinol
-
 ?
NADH + ubiquinone-1
-
 Plasmodium falciparum NAD+ + ubiquinol-1
-
 ?

Synonyms

Synonyms Comment Organism
alternative complex I
-
 Plasmodium falciparum
alternative NADH oxidoreductase
-
 Plasmodium falciparum
NDH2
-
 Plasmodium falciparum
type II NADH:dehydrogenase
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Plasmodium falciparum