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Literature summary for 7.1.1.2 extracted from

  • Peng, G.; Fritzsch, G.; Zickermann, V.; Schagger, H.; Mentele, R.; Lottspeich, F.; Bostina, M.; Radermacher, M.; Huber, R.; Stetter, K.O.; Michel, H.
    Isolation, characterization and electron microscopic single particle analysis of the NADH:ubiquinone oxidoreductase (complex I) from the hyperthermophilic eubacterium Aquifex aeolicus (2003), Biochemistry, 42, 3032-3039.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-n-decyl-quinazoline-4-yl-amine IC50: 0.0004 mM Aquifex aeolicus
rotenone IC50: 0.002 mM Aquifex aeolicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
520000
-
above, gel filtration Aquifex aeolicus

Organism

Organism UniProt Comment Textmining
Aquifex aeolicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Aquifex aeolicus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Aquifex aeolicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + 6-decyl-ubiquinone
-
Aquifex aeolicus NAD+ + 6-decyl-ubiquinol
-
?

Subunits

Subunits Comment Organism
More may contain up to 14 subunits Aquifex aeolicus

Synonyms

Synonyms Comment Organism
complex I
-
Aquifex aeolicus
NADH:ubiquinone oxidoreductase
-
Aquifex aeolicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
80
-
half-life: 10 h Aquifex aeolicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
4.5
-
1 h, stable Aquifex aeolicus
9
-
1 h, about 50% loss of activity Aquifex aeolicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Aquifex aeolicus

pI Value

Organism Comment pI Value Maximum pI Value
Aquifex aeolicus isoelectric focusing
-
6.2

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
IC50: 0.0004 mM Aquifex aeolicus 2-n-decyl-quinazoline-4-yl-amine
0.002
-
IC50: 0.002 mM Aquifex aeolicus rotenone