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Literature summary for 7.1.1.2 extracted from

  • Seo, B.B.; Kitajima-Ihara, T.; Chan, E.K.L.; Scheffler, I.E.; Matsuno-Yagi, A.; Yagi, T.
    Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells (1998), Proc. Natl. Acad. Sci. USA, 95, 9167-9171.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine the NDI1 gene provides a potentially useful tool for gene therapy of mitochondrial diseases caused by complex I deficiency Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
the NDI1 gene encoding the rotenone-insensitive internal NADH-quinone oxidoreductase is cotransfected into complex-I-deficient Chinese hamster CCL16-B2 cells. The enzyme is expressed functionally and catalyzes electron transfer from NADH in the matrix to ubiquinone 10 in the inner mitochonbdrial membranes Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
rotenone rotenone-insensitive enzyme Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 rotenone-insensitive enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone
-
 Saccharomyces cerevisiae NAD+ + ubiquinol
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Saccharomyces cerevisiae