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Literature summary for 7.1.1.2 extracted from
- Purification and characterization of a doxorubicin-inhibited NADH-quinone (NADH-ferricyanide) reductase from rat liver plasma membranes (2002), J. Biol. Chem., 277, 16441-16447.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the doxorubicin-inhibited NADH-quinone-reductase may provide a target for the anthracycline antitumor agents | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| doxorubicin | maximal inhibition at 0.001 mM | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
x * 57000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.186 | - |
NADH-ubiquinone-0 oxidoreductase activity | Rattus norvegicus |
| 10.3 | - |
NADH-ferricyanide oxidoreductase activity | Rattus norvegicus |
| 10.3 | - |
reduction of K3Fe(CN)6 | Rattus norvegicus |
| 13.2 | - |
reduction of Coenzyme Q10 | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + coenzyme Q10 | - |
Rattus norvegicus | ? | - |
? | |
| NADH + Fe(CN)63- | - |
Rattus norvegicus | ? | - |
? | |
| NADH + ubiquinone | - |
Rattus norvegicus | NAD+ + ubiquinol | - |
? | |
| NADH + ubiquinone-0 | - |
Rattus norvegicus | NAD+ + ubiquinol-0 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 57000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NADH-quinone (NADH-ferricyanide) reductase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Rattus norvegicus | |
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