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Literature summary for 7.1.1.2 extracted from

  • Hatefi, Y.
    The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system (1976), The Enzymes of Biological Membranes (Martonosi, A. V. , ed. ) Plenum, New York, 4, 3-41.
No PubMed abstract available
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
barbiturates
-
 Bos taurus
Demerol
-
 Bos taurus
piercidin A
-
 Bos taurus
rotenone
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
 NADH reaction with ferricyanide Bos taurus
0.012
-
 ferricytochrome c
-
 Bos taurus
0.014
-
 NADH reaction with cytochrome c Bos taurus
4
-
 ferricyanide
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Iron contains 4 major iron centers, contains 16-18 gatoms of iron per 650000 Da enzyme Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein the enzyme complex contains 0.22 mg of lipid per 650000 Da enzyme Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricyanide + NADH activity is 27.4fold of the activity with ubiquinone-1 Bos taurus 2 ferrocyanide + NAD+ + H+
-
 ?
2 ferricyanide + NADPH 0.13% of the activity with NADH and ferricyanide Bos taurus 2 ferrocyanide + NADP+ + H+
-
 ?
2 ferricytochrome c + NADH 12%-16% of the activity with ubiquinone-1 Bos taurus 2 ferrocytochrome c + NAD+ + H+
-
 ?
NADH + 2-methylnaphthoquinone 7.6% of the activity with ubiquinone-1 Bos taurus NAD+ + 2-methylnaphthalene-1,4-diol
-
 ?
NADH + ferricytochrome c
-
 Bos taurus NAD+ + H+ + ferrocytochrome c
-
 ?
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?
NADH + ubiquinone-1
-
 Bos taurus NAD+ + ubiquinol-1
-
 ?
NADH + ubiquinone-6 86% of the activity with ubiquinone-1 Bos taurus NAD+ + ubiquinol-6
-
 ?

Subunits

Subunits Comment Organism
More the enzyme complex is composed of at least 10 polypeptides ranging in MW from 10000 Da to 70000 Da Bos taurus

Cofactor

Cofactor Comment Organism Structure
FMN contains 1 FMN per 650000 Da enzyme Bos taurus
NADH
-
 Bos taurus
Ubiquinone-10 the enzyme contains 4.2-4.5 mol of ubiquinone-10 per 650000 Da enzyme Bos taurus